Long-Term Memory Deficits in Pavlovian Fear Conditioning in Ca /Calmodulin Kinase Kinase -Deficient Mice

نویسندگان

  • Frank Blaeser
  • Matthew J. Sanders
  • Nga Truong
  • Shanelle Ko
  • Long Jun Wu
  • David F. Wozniak
  • Michael S. Fanselow
  • Min Zhuo
  • Talal A. Chatila
چکیده

Long-Term Memory Deficits in Pavlovian Fear Conditioning in Ca /Calmodulin Kinase Kinase -Deficient Mice Frank Blaeser, Matthew J. Sanders, Nga Truong, Shanelle Ko, Long Jun Wu, David F. Wozniak, Michael S. Fanselow, Min Zhuo, and Talal A. Chatila* Institute of Transfusion Medicine, University of Leipzig, Leipzig, Germany; Department of Psychology, University of California at Los Angeles, Los Angeles, California 90095; Department of Pediatrics, The David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095; Department of Physiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8; and Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Long-term memory deficits in Pavlovian fear conditioning in Ca2+/calmodulin kinase kinase alpha-deficient mice.

Signaling by the Ca(2+)/calmodulin kinase (CaMK) cascade has been implicated in neuronal gene transcription, synaptic plasticity, and long-term memory consolidation. The CaM kinase kinase alpha (CaMKKalpha) isoform is an upstream component of the CaMK cascade whose function in different behavioral and learning and memory paradigms was analyzed by targeted gene disruption in mice. CaMKKalpha mut...

متن کامل

Hitting Ras where it counts: Ras antagonism in the basolateral amygdala inhibits long-term fear memory.

Several studies have implicated the Ras/mitogen-activated protein kinase (MAPK) pathway in Pavlovian fear conditioning. RasGRF1 knockout mice show significant deficits in acquisition of long-term fear memories and long-term potentaition (LTP) in the basolateral amygdala (BLA). MAPK kinase inhibition also impairs fear conditioning and amygdaloid LTP. However, there is no direct evidence to date ...

متن کامل

Sex-dependent up-regulation of two splicing factors, Psf and Srp20, during hippocampal memory formation.

Gene transcription is required for long-term memory (LTM) formation. LTM formation is impaired in a male-specific manner in mice lacking either of the two Ca(2+)/calmodulin-dependent kinase kinase (Camkk) genes. Since altered transcription was suggested to cause these impairments in LTM formation, we used microarrays to screen for CaMKKbeta-dependent gene expression changes. Here we show that t...

متن کامل

Impaired synaptic plasticity and cAMP response element-binding protein activation in Ca2+/calmodulin-dependent protein kinase type IV/Gr-deficient mice.

The Ca(2+)/calmodulin-dependent protein kinase type IV/Gr (CaMKIV/Gr) is a key effector of neuronal Ca(2+) signaling; its function was analyzed by targeted gene disruption in mice. CaMKIV/Gr-deficient mice exhibited impaired neuronal cAMP-responsive element binding protein (CREB) phosphorylation and Ca(2+)/CREB-dependent gene expression. They were also deficient in two forms of synaptic plastic...

متن کامل

Genetic Demonstration of a Role for PKA in the Late Phase of LTP and in Hippocampus-Based Long-Term Memory

To explore the role of protein kinase A (PKA) in the late phase of long-term potentiation (L-LTP) and memory, we generated transgenic mice that express R(AB), an inhibitory form of the regulatory subunit of PKA, only in the hippocampus and other forebrain regions by using the promoter from the gene encoding Ca2+/ calmodulin protein kinase IIalpha. In these R(AB) transgenic mice, hippocampal PKA...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2006